Accesso
Dott. PASQUALE DE BONIS
 
Data di nascita: 05/10/1979 Qualifica: DIRIGENTE MEDICO
Reparto: NEUROCHIRURGIA Numero di telefono dell'ufficio:
Fax dell'ufficio: E-Mail: p.debonis@ospfe.it
 
Titolo di studio:
Laurea in Medicina e Chirurgia conseguita il 28.7.2004 cum laude e bacio accademico presso l'Università Cattolica del Sacro Cuore, Roma Diploma di Specializzazione in Neurochirurgia conseguito il 12.11.2009 cum laude presso l'Università Cattolica del Sacro Cuore, Roma
 
Altri titoli di studio/professionali:
Dottorato di Ricerca in Neuroscienze presso l'Università Cattolica del Sacro Cuore, Roma
 
Esperienze professionali (incarichi):
-dal 01/02/2013 al 26/02/2013: Dirigente medico presso il Reparto di Neurochirurgia dell’ Ospedale Santa Maria Goretti Presidio Ospedaliero Nord ASL di Latina (contratto a tempo determinato in sostituzione di gravidanza) -dal 27/02/2013 al 26/02/2014: Dirigente medico presso il Reparto di Neurochirurgia dell’ Ospedale Sant’Anna di Ferrara (contratto a tempo determinato di un anno) -dal 19/03/2014 al 06/07/2014: Dirigente Medico con incarico Libero Professionale presso il Reparto di Neurochirurgia dell’Ospedale S. Anna di Ferrara. -dal 07/07/2014: Dirigente Medico a tempo Indeterminato presso il Reparto di Neurochirurgia dell’ Ospedale Sant’Anna di Ferrara
Competenze linguistiche:
Inglese -lettura: eccellente -scrittura: eccellente -espressione orale: eccellente Francese: -lettura: buona -scrittura: buona -espressione orale: buona
Competenze nell'uso delle tecnologie:
Conoscenza del microscopio operatorio, con filtro per 5-ALA; Neuronavigatore; Casco stereotassico di Leksell; Ecografo; Trans-cranial Doppler; Sistema di analisi della dinamica liquorale.  
Attività didattica:
Attività scientifica:
Abilitazione Scientifica Nazionale al settore 06/E3 (Neurochirurgia e Chirurgia Maxillo-facciale) per Professore di II fascia ottenuta nel mese di Febbraio 2014. Pubblicazioni scientifiche (allegato 1) Numero pubblicazioni su riviste peer-reviewed Internazionali con impact factor: 66 Impact factor totale (Aprile 2014): 272,35. Impact factor dei soli lavori in extenso(≥3pp) (Aprile 2014): 168,70 H-Index Scopus (Maggio 2014): 13 Capitoli di Libri: Coautore del Cap. 195 “Trauma cranico lieve, commozione cerebrale” del Trattato di Medicina interna. Ed. G. Gasbarrini. Verduci Editore 2011. Principali aree di ricerca: Neuro-oncologia, Neurotraumatologia, Chirurgia Spinale, Idrocefalo Attività di Editor (Editorial Board) per Riviste internazionali Peer-reviewed: Clinical Neurology and Neurosurgery (Elsevier), I.F. 1.240 BioMed Research International (Hindawi), I.F. 2.880 Interdisciplinary Neurosurgery: Advanced Techniques & Case Management (Elsevier) Attività di referee per riviste internazionali peer-reviewed: Neurosurgery; Journal of Neuroimaging; Clinical Neurology and Neurosurgery; Childs Nervous System; Expert Review of Neurotherapeutics; Neurological Research; BMC Neurology; Technology in Cancer Research and Treatment; Indian Journal of Cancer; International Journal of Medical Sciences. Rater del McMaster Online Rating of Evidence System dal 2008 (McMaster University Health Information Research Unit 1200 Main Street West, HSC-3H7 Hamilton, Ontario, CANADA) Premi di Studio ed altre Attività lavorative • Vincitore del Premio di Studio SINCh-Tekmed 2013 per un lavoro sulle “tecniche di monitoraggio multiparametrico nel trauma cranico” • “Award of Excellence in Reviewing” 2013 by Elsevier in recognition of an outstanding contribution to the quality of the journal (Clinical Neurology and Neurosurgery) Capitoli di Libri: Coautore del Cap. 195 “Trauma cranico lieve, commozione cerebrale” del Trattato di Medicina interna. Ed. G. Gasbarrini. Verduci Editore 2011. Pubblicazioni: 1. Mangiola A, De Bonis P, Guerriero M, Pompucci A, Anile C. Gliomatosis cerebri and pituitary adenoma: case report and literature review. J Neurooncol. 2005 Sep; 74 (3) :321-4. PubMed PMID:16132522. 2. Mangiola A, Maira G, De Bonis P, Porso M, Pettorini B, Sabatino G, Anile C. Glioblastoma multiforme in the elderly: a therapeutic challenge. J Neurooncol. 2006 Jan; 76 (2) :159-63. PubMed PMID:16132492. 3. Lama G, Mangiola A, Anile C, Sabatino G, De Bonis P, Lauriola L, Giannitelli C, La Torre G, Jhanwar-Uniyal M, Sica G, Maira G. Activated ERK1/2 expression in glioblastoma multiforme and in peritumor tissue. Int J Oncol. 2007 Jun; 30 (6) :1333-42. PubMed PMID:17487353. 4. Pompucci A, De Bonis P, Pettorini B, Petrella G, Di Chirico A, Anile C. Decompressive craniectomy for traumatic brain injury: patient age and outcome. J Neurotrauma. 2007 Jul; 24 (7) :1182-8. PubMed PMID:17610357. 5. Pompucci A, De Bonis P, Sabatino G, Federico G, Moschini M, Anile C, Mangiola A. Cranio-spinal subdural empyema due to S intermedius: a case report. J Neuroimaging. 2007 Oct; 17 (4) :358-60. PubMed PMID:17894630. 6. Cioni B, Meglio M, Perotti V, De Bonis P, Montano N. Neurophysiological aspects of chronic motor cortex stimulation. Neurophysiol Clin. 2007 Dec; 37 (6) :441-7. PubMed PMID:18083500. 7. Mangiola A, Lama G, Giannitelli C, De Bonis P, Anile C, Lauriola L, La Torre G, Sabatino G, Maira G, Jhanwar-Uniyal M, Sica G. Stem cell marker nestin and c-Jun NH2-terminal kinases in tumor and peritumor areas of glioblastoma multiforme: possible prognostic implications. Clin Cancer Res. 2007 Dec 1; 13 (23) :6970-7. PubMed PMID:18056172. 8. De Bonis P, Anile C, Tamburrini G, Tartaglione T, Mangiola A. Adult idiopathic occlusion of the foramina of Monro: diagnostic tools and therapy. J Neuroimaging. 2008 Jan; 18 (1) :101-4. PubMed PMID:18190506. 9. Montano N, Lauriola L, Colosimo C, Cioni B, Bonis PD, Papacci F, Meglio M. Intramedullary thrombosed venous ectasia mimicking hemangioblastoma. Eur J Neurol. 2008 Feb; 15 (2) :e10-11. PubMed PMID:18320640. 10. De Bonis P, Novegno F, Tamburrini G, Anile C, Pompucci A, Mangiola A. Teaching NeuroImage: Prepontine-suprasellar arachnoid cyst presenting with signs of normal pressure hydrocephalus. Neurology. 2008 Feb 5; 70 (6) :e26. PubMed PMID:18250284. 11. Montano N, De Bonis P, Doglietto F, Cianfoni A, Pallini R, Lauriola L, Maira G. Teaching NeuroImage: hemorrhagic ependymoma in the elderly: a rare cause of headache and gait imbalance. Neurology. 2008 Jun 3; 70 (23) :e95. PubMed PMID:18519865. 12. Montano N, De Bonis P, Lauriola L, Papacci F, Lucantoni C, Colosimo C, Cioni B, Meglio M. Late onset cerebellar metastasis from oesophageal adenocarcinoma in Williams Syndrome. J Neurooncol. 2008 Jul; 88 (3) :349-51. PubMed PMID:18392775. 13. Mangiola A, de Bonis P, Maira G, Balducci M, Sica G, Lama G, Lauriola L, Anile C. Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme. Cancer. 2008 Aug 15; 113 (4) :841-6. PubMed PMID:18618580. 14. De Bonis P, Lucantoni C, D'Angelo L, Doglietto F, Romano D, Visocchi M. Teaching NeuroImage: spinal extradural arachnoid cyst: a rare cause of back pain. Neurology. 2008 Aug 26; 71 (9) :e24. PubMed PMID:18725585. 15. Montano N, Nucci CG, Doglietto F, Cianfoni A, Lucantoni C, De Bonis P, Tamburrini G, Visocchi M. Teaching NeuroImage: Spontaneous idiopathic spinal subdural hematoma. Neurology. 2008 Sep 2; 71 (10) :e27. PubMed PMID:18765644. 16. Anile C, De Bonis P, Di Chirico A, Ficola A, Mangiola A, Petrella G. Cerebral blood flow autoregulation during intracranial hypertension: a simple, purely hydraulic mechanism?. Childs Nerv Syst. 2009 Mar; 25 (3) :325-35; discussion 337-40. PubMed PMID:19152096. 17. Massimi L, De Bonis P, Esposito G, Novegno F, Pettorini B, Tamburrini G, Caldarelli M, Di Rocco C. Vertex scalp mass as presenting sign of a complex intracranial vascular malformation. J Neurosurg Pediatr. 2009 Apr; 3 (4) :307-10. PubMed PMID:19338409. 18. De Bonis P, Montano N, Cioni B, Colosimo C, Lauriola L, Papacci F, Meglio M. Primary extramedullary extradural ependymoma of the thoracic spine mimicking a schwannoma. J Neurol Neurosurg Psychiatry. 2009 May; 80 (5) :579-81. PubMed PMID:19372297. 19. De Bonis P, Anile C, Pompucci A, Labonia M, Lucantoni C, Mangiola A. Cranial and spinal subdural empyema. Br J Neurosurg. 2009 Jun; 23 (3) :335-40. PubMed PMID:19533473. 20. Pettorini BL, Novegno F, Cianfoni A, Massimi L, De Bonis P, Esposito G, Caldarelli M, Tamburrini G, Di Rocco C, Giangaspero F, Lauriola L. 5-year-old boy with a clival mass. Brain Pathol. 2009 Jul; 19 (3) :523-6. PubMed PMID:19563544. 21. Lucantoni C, De Bonis P, Doglietto F, Esposito G, Larocca LM, Mangiola A, Martini M, Papacci F, Teofili L, Pompucci A. Primary cerebral lymphomatoid granulomatosis: report of four cases and literature review. J Neurooncol. 2009 Sep; 94 (2) :235-42. PubMed PMID:19322520. 22. Albanese A, De Bonis P, Sabatino G, Capone G, Marchese E, Vignati A, Maira G. Antibiotic-impregnated ventriculo-peritoneal shunts in patients at high risk of infection. Acta Neurochir (Wien). 2009 Oct; 151 (10) :1259-63. PubMed PMID:19390777. 23. Esposito G, de Bonis P, Tamburrini G, Massimi L, Byvaltsev V, di Rocco C, Leone A. Unilateral hyperplasia of the left posterior arch and associated vertebral schisis at C6 level. Skeletal Radiol. 2009 Dec; 38 (12) :1191-5. PubMed PMID:19633840. 24. Mangiola A, Anile C, Pompucci A, Capone G, Rigante L, De Bonis P. Glioblastoma therapy: going beyond Hercules Columns. Expert Rev Neurother. 2010 Apr; 10 (4) :507-14. PubMed PMID:20367204. 25. De Bonis P, Pompucci A, Mangiola A, D'Alessandris QG, Rigante L, Anile C. Decompressive craniectomy for the treatment of traumatic brain injury: does an age limit exist?. J Neurosurg. 2010 May; 112 (5) :1150-3. PubMed PMID:19645536. 26. Anile C, De Bonis P, Albanese A, Di Chirico A, Mangiola A, Petrella G, Santini P. Selection of patients with idiopathic normal-pressure hydrocephalus for shunt placement: a single-institution experience. J Neurosurg. 2010 Jul; 113 (1) :64-73. PubMed PMID:20151782. 27. Cianfoni A, Calandrelli R, De Bonis P, Pompucci A, Lauriola L, Colosimo C. Nocardia brain abscess mimicking high-grade necrotic tumor on perfusion MRI. J Clin Neurosci. 2010 Aug; 17 (8) :1080-2. PubMed PMID:20488710. 28. Balducci M, Apicella G, Manfrida S, Mangiola A, Fiorentino A, Azario L, D'Agostino GR, Frascino V, Dinapoli N, Mantini G, Albanese A, de Bonis P, Chiesa S, Valentini V, Anile C, Cellini N. Single-arm phase II study of conformal radiation therapy and temozolomide plus fractionated stereotactic conformal boost in high-grade gliomas: final report. Strahlenther Onkol. 2010 Oct; 186 (10) :558-64. PubMed PMID:20936460. 29. De Bonis P, Pompucci A, Mangiola A, Rigante L, Anile C. Post-traumatic hydrocephalus after decompressive craniectomy: an underestimated risk factor. J Neurotrauma. 2010 Nov; 27 (11) :1965-70. PubMed PMID:20812777. 30. Sica G, Lama G, Anile C, Geloso MC, La Torre G, De Bonis P, Maira G, Lauriola L, Jhanwar-Uniyal M, Mangiola A. Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma. Int J Oncol. 2011 Jan; 38 (1) :41-9. PubMed PMID:21109924. 31. De Bonis P, Mangiola A, Pompucci A, Anile C. Decompressive craniectomy and hydrocephalus. Neurosurgery. 2011 Jun; 68 (6) :E1777-8; author reply E1778-9. PubMed PMID:21389892. 32. De Bonis P, Albanese A, Lofrese G, de Waure C, Mangiola A, Pettorini BL, Pompucci A, Balducci M, Fiorentino A, Lauriola L, Anile C, Maira G. Postoperative infection may influence survival in patients with glioblastoma: simply a myth?. Neurosurgery. 2011 Oct; 69 (4) :864-8; discussion 868-9. PubMed PMID:21900810. 33. De Bonis P, Pompucci A, Mangiola A, Paternoster G, Festa R, Nucci CG, Maviglia R, Antonelli M, Anile C. Decompressive Craniectomy for Elderly Patients with Traumatic Brain Injury: It's Probably not Worth the While. J Neurotrauma. 2011 Oct; 28 (10) :2043-8. PubMed PMID:21639728. 34. Calcagni ML, Lavalle M, Mangiola A, Indovina L, Leccisotti L, De Bonis P, Marra C, Pelliccioni A, Anile C, Giordano A. Early evaluation of cerebral metabolic rate of glucose (CMRglu) with (18)F-FDG PET/CT and clinical assessment in idiopathic normal pressure hydrocephalus (INPH) patients before and after ventricular shunt placement: preliminary experience. Eur J Nucl Med Mol Imaging. 2011 Oct 13; PubMed PMID:21993525. 35. De Bonis P, Frassanito P, Nucci CG, Mangiola A, Anile C, Pompucci A. Cranial repair: how complicated is filling a “hole”. J Neurotrauma. 2011 Nov 8; PubMed PMID:22059899. 36. De Bonis P, Cingolani A, Pompucci A, Tartaglione T, Larocca LM, Teofili L. Cauda Equina Enhancing Lesion in an HIV-Infected Patient. Case Report and Literature Review. Mediterr J Hematol Infect Dis 2011, 3: e2011042, DOI 10.4084/MJHID.2011.042 37. Anile C, De Bonis P, Ficola A, Santini P, Mangiola A. An experimental study on artificially induced CSF pulse waveform morphological modifications. Neurol Res. 2011 Dec;33(10):1072-82 38. Frassanito P, De Bonis P, Caputo CG, Mangiola A, Pompucci A, Nucci CG, Trevisi G, Anile C. "Blinding" empty sella: can lumbar puncture be avoided? Arch Neurol 2012 Mar 12 39. Mangiola A, Calcagni ML, De Bonis P, Rigante L, Pompucci A, La Valle MD, Indovina L, Giordano A, Anile C. Cerebral metabolic rate for glucose of NPH patients increases in shunt-reponders. J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):466-7. 40. Frassanito P, De Bonis P, Mattogno PP, Novello M, Anile C. Hormonal therapy for fertility and huge meningioma: a purely random association? Acta Neurol Belg. 2012 Feb 15. 41. Masciullo M, Mattogno PP, Modoni A, Silvestri G, De Bonis P. Subdural hematoma in a young woman with an "old" brain. Acta Neurol Belg. 2012 Mar 9. 42. De Bonis P, Anile C, Pompucci A, Fiorentino A, Balducci M, Chiesa S, Lauriola L, Maira G, Mangiola A. The influence of surgery on recurrence pattern of Glioblastoma. Clin Neurol Neurosurg. 2012 Apr 24. 43. De Bonis P, Mangiola A, Pompucci A, Formisano R, Mattogno P, Anile C. CSF dynamics analysis in patients with post-traumatic ventriculomegaly. Clin Neurol Neurosurg. 2012 May 15. 44. Balducci M, Fiorentino A, De Bonis P, Chiesa S, Manfrida S, D’Agostino GR, Mantini G, Frascino V, Mattiucci GC, De Bari B, Mangiola A, Micciche` F, Gambacorta MA, Colicchio G, Morganti AG, Anile C, Valentini V. Impact of age and co-morbidities in patients with newly diagnosed glioblastoma: a Pooled Data Analysis of Three Prospective Mono-institutional Phase II Studies. Medical Oncology 2012 Dec;29(5):3478-83. 45. Doglietto F, Colosimo C, Lauriola L, Balducci M, De Bonis P, Montano N, Zadeh G, Maira G, Pallini R. Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review. BMC Cancer. 2012 Jun 6;12(1):220 46. De Bonis P, Anile C, Pompucci A, Fiorentino A, Balducci M, Chiesa S, Maira G, Mangiola A. Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent Glioblastoma. Acta Neurochirurgica 2012 Aug;154(8):1371-8 47. De Bonis P, Mattogno PP, De Simone C, Pompucci A, Mangiola A. A strange case of "postural monoparesis" Acta Neurol Belg. 2012 Jun 28. 48. De Bonis P, Mattogno PP, Capone G, Mangiola A, Anile C. A rare cause of CSF shunt "failure" in a patient with NPH. Acta Neurol Belg. 2012 Jul 7. 49. Anile C, De Bonis P, Fernandez E, Ficola A, Petrella G, Santini P, Mangiola A. Blood flow velocities during experimental intracranial hypertension in pigs. Neurol Res 2012 Nov;34(9):859-63 50. De Bonis P, Tamburrini G, Mangiola A, Pompucci A, Mattogno P, Porso M, Anile C. Post-traumatic hydrocephalus is a contraindication for endoscopic third-ventriculostomy: isn't it? Clin Neurol Neurosurg 2013 Jan;115(1):9-12 51. Sturiale CL, De Bonis P, Rigante L, Calandrelli R, D’Arrigo S, Pompucci A, Mangiola A, D’Apolito G, Colosimo C, Anile C. Do traumatic brain contusions increase in size after decompressive craniectomy? J Neurotrauma 2012 Aug 8 52. De Bonis P, Doglietto, F, Anile C, Pompucci A, Mangiola A. Electric Fields for the Treatment of Glioblastoma. Exp Rev Neurother 2012 Oct;12(10):1181-4 53. De Bonis P, Mangiola A, Pompucci A, Porso M, Anile C. High-grade Glioma: Elderly Patients, Older Treatments. Exp Rev Neurother 2012 Nov;12(11):1293–1296 54. De Bonis P, Fiorentino A, Anile C, Pompucci A, Balducci M, Chiesa S, Sica G, Lama G, Maira G, Mangiola. A The impact of repeated surgery and adjuvant therapy on survival for patients with recurrent glioblastoma. Clin Neurol Neurosurg 2012 Sep 6 55. Frassanito P, De Bonis P, Mangiola A, Mattogno PP, Novello M, Brinchi D, Pompucci A. Anile C. The fate of a macroporous hydroxyapatite cranioplasty four years after implantation: macroscopical and microscopical findings in a case of recurrent atypical meningioma. Clin Neurol Neurosurg 2012 (in press). 56. De Bonis P, Sturiale CL, Anile C, Gaudino S, Mangiola A, Martucci M, Rigante L, Pompucci A. Decompressive craniectomy, interhemispheric hygroma and hydrocephalus: a timeline of events? Clin Neurol Neurosurg 2012 (in press). 57. Binda E, Visioli A, Giani F, Lamorte G, Copetti M, Pitter KL, Huse JT, Cajola L, Zanetti N, Dimeco F, De Filippis L, Mangiola A, Maira G, Anile C, De Bonis P, Reynolds BA, Pasquale EB, Vescovi AL. The EphA2 Receptor Drives Self-Renewal and Tumorigenicity in Stem-like Tumor-Propagating Cells from Human Glioblastomas. Cancer Cell, Dec 11;22(6):765-80. 58. Fiorentino A, Balducci M, De Bonis P, Chiesa S, De Filippo L, Mangiola A, De Rose F, Autorino R, Rinaldi C, Fersino S, Diletto B, Matteucci P, Ciurlia E, Fusco V, Anile C, Valentini V. Can Elderly Patients with Newly Diagnosed Glioblastoma Be Enrolled in Radiochemotherapy Trials? American Journal of Clinical Oncology 2013 (in press). 59. Mangiola A, Saulnier N, De Boni P, Orteschi D, Sica G, Lama G, Pettorini BL, Sabatino G, Zollino M, Lauriola L, Colabianchi A, Proietti G, Kovacs G, Maira G, Anile C. Gene Expression Profile of Glioblastoma Peritumoral Tissue: an ex vivo Study. PLOS One 2013 (in press) 60. De Bonis P, Anile C, Honeybul S. Intracranial Pressure and Brain Injury: Can a Monitor Improve Outcome? The New England Journal of Medicine 2013 (in press) 61. Calcagni ML, Taralli S, Mangiola A, Indovina L, Lavalle MD, De Bonis P, Anile C, Giordano A. Regional metabolic rate of glucose (CMRglu) evaluation and clinical assessment in idiopathic normal-pressure hydrocephalus (iNPH) patients before and after ventricular shunt placement. A prospective analysis. Clinical Nuclear Medicine 2013 (in press)
Interessi clinici e/o scientifici:
Neuro-oncologia, Neurotraumatologia, Chirurgia Spinale, Idrocefalo