Accesso
Dott. PAOLA RIMESSI
 
Data di nascita: 21/01/1962 Qualifica: DIRIGENTE BIOLOGO - LAB. GENETICA MEDICA
Reparto: GENETICA MEDICA Numero di telefono dell'ufficio: 0532-974419
Fax dell'ufficio: E-Mail: p.rimessi@ospfe.it
 
Titolo di studio:
Laurea in Scienze Biologiche
 
Altri titoli di studio/professionali:
Dottorato di Ricerca in Biotecnologie Specialità in Genetica Medica Cultore di materia in Microbiologia
 
Esperienze professionali (incarichi):
2003-2007 Azienda Ospedaliera Universitaria di Ferrara Sezione di Genetica Medica Contratto libero-professionale Biologo, per attività di Diagnostica Molecolare Ottobre 2007 Vincitore di un concorso per Dirigente Biologo I Livello presso la U.O. di Genetica Medica. Ottobre 2008 Assunzione presso la U.O. di Genetica Medica.
Competenze linguistiche:
Inglese parlato e scritto
Competenze nell'uso delle tecnologie:
Tecniche di diagnostica molecolare su DNA ed RNA Tecniche di biologia molecolare Colture cellulari Utilizzo di modelli animali per lo studio della distrofia muscolare  
Attività didattica:
Docente 1° e 2°anno della scuola di specialità in Genetica Medica: Tecnologie ricombinanti (6 ore) e Biotecnologie genetiche metodologiche (5 ore).
Attività scientifica:
1.Association of CYP1B1 with hypersensitivity induced by taxane therapy in breast cancer patients. Rizzo R, Spaggiari F, Indelli M, Lelli G, Baricordi OR, Rimessi P, Ferlini A. Breast Cancer Res Treat. 2010 Nov;124(2):593-8. Epub 2010 Jul 15. 2.Antisense modulation of both exonic and intronic splicing motifs induces skipping of a DMD pseudo-exon responsible for x-linked dilated cardiomyopathy. Rimessi P, Fabris M, Bovolenta M, Bassi E, Falzarano S, Gualandi F, Rapezzi C, Coccolo F, Perrone D, Medici A, Ferlini A. Hum Gene Ther. 2010 Sep;21(9):1137-46. 3.Preclinical PK and PD studies on 2'-O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model. Heemskerk H, de Winter C, van Kuik P, Heuvelmans N, Sabatelli P, Rimessi P, Braghetta P, van Ommen GJ, de Kimpe S, Ferlini A, Aartsma-Rus A, van Deutekom JC. Mol Ther. 2010 Jun;18(6):1210-7. Epub 2010 Apr 20. 4.Brody disease: insights into biochemical features of SERCA1 and identification of a novel mutation. Vattemi G, Gualandi F, Oosterhof A, Marini M, Tonin P, Rimessi P, Neri M, Guglielmi V, Russignan A, Poli C, van Kuppevelt TH, Ferlini A, Tomelleri G. J Neuropathol Exp Neurol. 2010 Mar;69(3):246-52. 5.Prenatal diagnosis of Duchenne muscular dystrophy by comparative genomic hybridization. Bovolenta M, Rimessi P, Dolcini B, Ravani A, Ferlini A, Gualandi F. Clin Genet. 2010 May;77(5):503-6. Epub 2009 Dec 10. No abstract available. 6.Dystrophin restoration in skeletal, heart and skin arrector pili smooth muscle of mdx mice by ZM2 NP-AON complexes. Ferlini A, Sabatelli P, Fabris M, Bassi E, Falzarano S, Vattemi G, Perrone D, Gualandi F, Maraldi NM, Merlini L, Sparnacci K, Laus M, Caputo A, Bonaldo P, Braghetta P, Rimessi P. Gene Ther. 2010 Mar;17(3):432-8. Epub 2009 Nov 12. 7.Exon skipping-mediated dystrophin reading frame restoration for small mutations. Spitali P, Rimessi P, Fabris M, Perrone D, Falzarano S, Bovolenta M, Trabanelli C, Mari L, Bassi E, Tuffery S, Gualandi F, Maraldi NM, Sabatelli-Giraud P, Medici A, Merlini L, Ferlini A. Hum Mutat. 2009 Nov;30(11):1527-34. 8.Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse. Rimessi P, Sabatelli P, Fabris M, Braghetta P, Bassi E, Spitali P, Vattemi G, Tomelleri G, Mari L, Perrone D, Medici A, Neri M, Bovolenta M, Martoni E, Maraldi NM, Gualandi F, Merlini L, Ballestri M, Tondelli L, Sparnacci K, Bonaldo P, Caputo A, Laus M, Ferlini A. Mol Ther. 2009 May;17(5):820-7. Epub 2009 Feb 24. 9.A novel custom high density-comparative genomic hybridization array detects common rearrangements as well as deep intronic mutations in dystrophinopathies. Bovolenta M, Neri M, Fini S, Fabris M, Trabanelli C, Venturoli A, Martoni E, Bassi E, Spitali P, Brioschi S, Falzarano MS, Rimessi P, Ciccone R, Ashton E, McCauley J, Yau S, Abbs S, Muntoni F, Merlini L, Gualandi F, Ferlini A. BMC Genomics. 2008 Nov 28;9:572. 10.Transcriptional behavior of DMD gene duplications in DMD/BMD males. Gualandi F, Neri M, Bovolenta M, Martoni E, Rimessi P, Fini S, Spitali P, Fabris M, Pane M, Angelini C, Mora M, Morandi L, Mongini T, Bertini E, Ricci E, Vattemi G, Mercuri E, Merlini L, Ferlini A. Hum Mutat. 2009 Feb;30(2):E310-9. 11.Dystrophin levels as low as 30% are sufficient to avoid muscular dystrophy in the human. Neri M, Torelli S, Brown S, Ugo I, Sabatelli P, Merlini L, Spitali P, Rimessi P, Gualandi F, Sewry C, Ferlini A, Muntoni F. Neuromuscul Disord. 2007 Dec;17(11-12):913-8. Epub 2007 Sep 7. 12.Phenotypic and genotypic heterogeneity in transthyretin-related cardiac amyloidosis: towards tailoring of therapeutic strategies? Rapezzi C, Perugini E, Salvi F, Grigioni F, Riva L, Cooke RM, Ferlini A, Rimessi P, Bacchi-Reggiani L, Ciliberti P, Pastorelli F, Leone O, Bartolomei I, Pinna AD, Arpesella G, Branzi A. Amyloid. 2006 Sep;13(3):143-53. 13.Commercial kit-based diagnosis is not enough for prenatal testing of beta-thalassemia: pitfalls in diagnostic mutation analysis raises the need for reference laboratories. Ferlini A, Ravani A, Venturoli A, Trabanelli C, Masieri MT, Brandi A, Dolcini B, Rimessi P, Gualandi F, Calzolari E. Prenat Diagn. 2006 Oct;26(10):989-91. No abstract available. 14.Transthyretin RNA profiling in livers from transplanted patients affected by familial amyloidotic polyneuropathy, and identification of a dual transcription start point. Rimessi P, Spitali P, Ando Y, Mazzaferro V, Pastorelli F, Tassinari CA, Calzolari E, Salvi F, Ferlini A. Liver Int. 2006 Mar;26(2):211-20. 15.Intronic breakpoint definition and transcription analysis in DMD/BMD patients with deletion/duplication at the 5' mutation hot spot of the dystrophin gene. Gualandi F, Rimessi P, Trabanelli C, Spitali P, Neri M, Patarnello T, Angelini C, Yau SC, Abbs S, Muntoni F, Calzolari E, Ferlini A. Gene. 2006 Mar 29;370:26-33. Epub 2006 Jan 24. 16.Genomic and transcription studies as diagnostic tools for a prenatal detection of X-linked dilated cardiomyopathy due to a dystrophin gene mutation. Rimessi P, Gualandi F, Duprez L, Spitali P, Neri M, Merlini L, Calzolari E, Muntoni F, Ferlini A. Am J Med Genet A. 2005 Feb 1;132(4):391-4. 17.HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity. Gavioli R, Gallerani E, Fortini C, Fabris M, Bottoni A, Canella A, Bonaccorsi A, Marastoni M, Micheletti F, Cafaro A, Rimessi P, Caputo A, Ensoli B. J Immunol. 2004 Sep 15;173(6):3838-43. 18.In vivo study of an aberrant dystrophin exon inclusion in X-linked dilated cardiomyopathy. Cohen N, Rimessi P, Gualandi F, Ferlini A, Muntoni F. Biochem Biophys Res Commun. 2004 May 14;317(4):1215-20. 19.Tempo and mode of evolution of a primate-specific retrotransposon belonging to the LINE 1 family. Cardazzo B, Bargelloni L, Toffolatti L, Rimessi P, Ferlini A, Patarnello T. J Mol Evol. 2003;57 Suppl 1:S268-76. 20.Atypical familial motor neuropathy in patients with mutant TTR Ile68Leu. Salvi F, Scaglione C, Michelucci R, Linke RP, Obici L, Ravani A, Rimessi P, Ferlini A, Meletti S, Cavallaro T, Tassinari CA, Martinelli P. Amyloid. 2003 Sep;10(3):185-9. 21.Multiple exon skipping and RNA circularisation contribute to the severe phenotypic expression of exon 5 dystrophin deletion. Gualandi F, Trabanelli C, Rimessi P, Calzolari E, Toffolatti L, Patarnello T, Kunz G, Muntoni F, Ferlini A. J Med Genet. 2003 Aug;40(8):e100. No abstract available. 22.Genomic definition of a pure intronic dystrophin deletion responsible for an XLDC splicing mutation: in vitro mimicking and antisense modulation of the splicing abnormality. Gualandi F, Rimessi P, Cardazzo B, Toffolatti L, Dunckley MG, Calzolari E, Patarnello T, Muntoni F, Ferlini A. Gene. 2003 Jun 5;311:25-33. 23.Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8. Micheletti F, Monini P, Fortini C, Rimessi P, Bazzaro M, Andreoni M, Giuliani M, Traniello S, Ensoli B, Gavioli R. Immunology. 2002 Jul;106(3):395-403. 24.Transcription pattern of human herpesvirus 8 open reading frame K3 in primary effusion lymphoma and Kaposi's sarcoma. Rimessi P, Bonaccorsi A, Stürzl M, Fabris M, Brocca-Cofano E, Caputo A, Melucci-Vigo G, Falchi M, Cafaro A, Cassai E, Ensoli B, Monini P. J Virol. 2001 Aug;75(15):7161-74. 25.Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies regions involved in ovarian cancer. Rimessi P, Gualandi F. Methods Mol Med. 2001;39:337-45. 26.A human melanoma metastasis-suppressor locus maps to 6q16.3-q23. Miele ME, Jewett MD, Goldberg SF, Hyatt DL, Morelli C, Gualandi F, Rimessi P, Hicks DJ, Weissman BE, Barbanti-Brodano G, Welch DR. Int J Cancer. 2000 May 15;86(4):524-8. 27.Multicenter comparison of PCR assays for detection of human herpesvirus 8 DNA in semen. Pellett PE, Spira TJ, Bagasra O, Boshoff C, Corey L, de Lellis L, Huang ML, Lin JC, Matthews S, Monini P, Rimessi P, Sosa C, Wood C, Stewart JA. J Clin Microbiol. 1999 May;37(5):1298-301. 28.Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells. Monini P, Carlini F, Stürzl M, Rimessi P, Superti F, Franco M, Melucci-Vigo G, Cafaro A, Goletti D, Sgadari C, Butto' S, Leone P, Chiozzini C, Barresi C, Tinari A, Bonaccorsi A, Capobianchi MR, Giuliani M, di Carlo A, Andreoni M, Rezza G, Ensoli B. J Virol. 1999 May;73(5):4029-41. 29.Human herpesvirus DNA in prostate and semen from HIV-negative individuals in Italy. Monini P, Howard MR, Rimessi P, de Lellis L, Schulz TF, Cassai E. AIDS. 1997 Oct;11(12):1530-2. No abstract available. 30.Characterization of a 4-Mb region at chromosome 6q21 harboring a replicative senescence gene. Morelli C, Sherratt T, Trabanelli C, Rimessi P, Gualandi F, Greaves MJ, Negrini M, Boyle JM, Barbanti-Brodano G. Cancer Res. 1997 Oct 1;57(19):4153-7. 31.Growth arrest and suppression of tumorigenicity of bladder-carcinoma cell lines induced by the P16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9. Wu Q, Possati L, Montesi M, Gualandi F, Rimessi P, Morelli C, Trabanelli C, Barbanti-Brodano G. Int J Cancer. 1996 Mar 15;65(6):840-6. 32.Physical analysis of part of band 6q21 harboring a putative tumor suppressor gene and a putative senescence gene. Morelli C, Sherratt T, Greaves MJ, Iwanejko L, Trabanelli C, Rimessi P, Gualandi F, Negrini M, Barbanti-Brodano G, Trent JM, Boyle JM. DNA Seq. 1996;7(1):43-5. No abstract available. 33.Complementation of bloom cellular phenotype by human chromosome 15. Sensi A, Bonfatti A, Gruppioni R, Gualandi F, Rimessi P, Trabanelli C, Barbanti-Brodano G, Stanbridge EJ. Cancer Genet Cytogenet. 1995 Apr;80(2):167. No abstract available. 34.A BK virus episomal vector for constitutive high expression of exogenous cDNAs in human cells. Sabbioni S, Negrini M, Rimessi P, Manservigi R, Barbanti-Brodano G. Arch Virol. 1995;140(2):335-9. 35.Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer. Rimessi P, Gualandi F, Morelli C, Trabanelli C, Wu Q, Possati L, Montesi M, Barrett JC, Barbanti-Brodano G. Oncogene. 1994 Dec;9(12):3467-74. 36.Induction of senescence and control of tumorigenicity in BK virus transformed mouse cells by human chromosome 6. Gualandi F, Morelli C, Pavan JV, Rimessi P, Sensi A, Bonfatti A, Gruppioni R, Possati L, Stanbridge EJ, Barbanti-Brodano G. Genes Chromosomes Cancer. 1994 Jun;10(2):77-84. 37.[Tumor suppressor genes. New perspectives for clinical investigations in cancer]. Paván J, Gualandi F, Rimessi P, Corallini A, Barbanti-Brodano G. Medicina (B Aires). 1994;54(2):163-8. Review. Spanish. 38.Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. Corallini A, Altavilla G, Pozzi L, Bignozzi F, Negrini M, Rimessi P, Gualandi F, Barbanti-Brodano G. Cancer Res. 1993 Nov 15;53(22):5569-75. 39.Suppression of tumorigenicity and anchorage-independent growth of BK virus-transformed mouse cells by human chromosome 11. Negrini M, Castagnoli A, Pavan JV, Sabbioni S, Araujo D, Corallini A, Gualandi F, Rimessi P, Bonfatti A, Giunta C, et al. Cancer Res. 1992 Mar 1;52(5):1297-303. 40.High expression of exogenous cDNAs directed by HIV-1 long terminal repeat in human cells constitutively producing HIV-1 tat and adenovirus E1A/E1B. Negrini M, Rimessi P, Sabbioni S, Caputo A, Balboni PG, Gualandri R, Manservigi R, Grossi MP, Barbanti-Brodano G. Biotechniques. 1991 Mar;10(3):344-53. 41.Characterization of BK virus variants rescued from human tumours and tumour cell lines. Negrini M, Rimessi P, Mantovani C, Sabbioni S, Corallini A, Gerosa MA, Barbanti-Brodano G. J Gen Virol. 1990 Nov;71 ( Pt 11):2731-6. 42.Protection from herpes simplex virus type 1 lethal and latent infections by secreted recombinant glycoprotein B constitutively expressed in human cells with a BK virus episomal vector. Manservigi R, Grossi MP, Gualandri R, Balboni PG, Marchini A, Rotola A, Rimessi P, Di Luca D, Cassai E, Barbanti-Brodano G. J Virol. 1990 Jan;64(1):431-6. 43.New BK virus episomal vector for complementary DNA expression in human cells. Grossi MP, Caputo A, Rimessi P, Chiccoli L, Balboni PG, Barbanti-Brodano G. Arch Virol. 1988;102(3-4):275-83.
Interessi clinici e/o scientifici:
Patologie neuromuscolari: Distrofia muscolare di Duchenne/Becker, Atrofia Muscolare Spinale (SMA). Neuropatie periferiche: CMT1A/HNPP. Modelli animali di distrofia muscolare di Duchenne. Sistemi di trasporto in vivo di molecole ad RNA.